Remarkable Weight Loss With Once Daily Semaglutide Pill
By Arvind Sommi
Early findings from a phase 3 clinical trial demonstrated that participants treated with 50 mg oral semaglutide achieved a remarkable weight loss of 17.4%. This research could lead to a once-daily pill alternative to popular weight loss injections such as Ozempic and Wegovy.
The groups in the trial received either oral semaglutide or a placebo in combination with lifestyle intervention. The trial results showed superior weight loss after 68-weeks among those taking the drug compared to the placebo.
“The results show comparable weight loss as in the STEP 1 trial with injectable semaglutide 2.4 mg in obesity branded as Wegovy,” Martin Holst Lange, executive vice president of development at Novo Nordisk, said in a statement.
From an average weight of 232.4 pounds, or 105.4 kg, individuals treated with 50 mg of oral semaglutide lost 17.4% on average of their body weight after 68 weeks, in contrast to a 1.8% reduction observed in the placebo group. Additionally, nearly 90% of the participants achieved a weight loss of at least 5%, compared to only 24.5% in the placebo group.
These findings are consistent with the PIONEER PLUS trial, which investigated the weight loss from high dose oral semaglutide for people with type 2 diabetes.
Oral semaglutide, available at 3 mg, 7 mg, and 14 mg doses and sold as Rybelsus, is currently used to treat type 2 diabetes. Wegovy, an injectable form of the same medication, is also approved for weight loss. If this high dose oral semaglutide eventually receives FDA approval, it could provide a choice between a daily tablet or a weekly injection, providing people with obesity and their healthcare providers options that best suit individual preferences.
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